FA16 Immunization Module’s Updates
Active versus passive immunization
Our immune systems is comprised of complicated mechanisms that in many ways we still do not completely understand. However, research has brought us to a point where we have learned effective methods to use the body's responses to protect us from very dangerous diseases. In order to understand immunizations, we must first look at the different types we can implement, and the underlying body's mechanisms we are using in order to generate immunity.
Active immunity refers to using the body's natural immune response to mount a response against a specific disease. This involves administration of a vaccine that will mount a response from the body's immune system, thus preparing it for an actual attack. This protection is mediated through the production of memory cells, which are specialized cells that will remember pathogens and protect the body in case of future attack. Active immunizations rely on the proper functioning of the body's immune system in order to provide protection from disease.
Passive immunity on the otherhand utilizess matured antibodies from a donor, and directly administered to the patient. This bypasses the patient's own immune system and provides them with the antibodies needed to adequately defend against infection. This method works well for patients with compromised immune systems. Passive immunization serves as protection for patients who would otherwise not be able to protect themselves from infection.
Both active and passive immunizations utilize naturally occuring processes of the body to provide protection. Passive immunization happens naturally as well, and can be seen in the interactions between a mother and a fetus. IgG antibodies from the mother are able to pass through the placenta and provide passive immunity to the developing child. Vaccinations use these principles of active and passive immunizations to protect people from potential pathogens that exist in our world. It is important to understand how immunizations work to fully comprehend their importance, and understand how they are truly benefiting us overall.
@Corey Mahler I was thinking about that too after posting. I'd imagine that they would probably have a short lived immunity- maybe a few days/ weeks?
@Katelyn Peters Your comment about snake venom makes me think of another question. I wonder if snake bite victims who survive a snake bite without antivenom develop a small amount of immunity to future snake bites.
@zoe Scharf I believe when we talked about this in class Dr. Tapping said that passive immunizations are not normally long term. For example babies get antibodies from breast feeding and once they stop the mother's antibodies don't stay in their systems long after. Another example I can think of off the top of my head is snake anti-venoms which are given to patients after a snake bite to avoid life threatening reactions, but these are specific to that specific snake's venom and aren't very broad at all, also they don't confer immunity to a future snake bite.
@Zoe Scharf These are great questions which I hope you classmates will weigh in on.
Is passive immunization typically used long term, or just short term against specific infections? Can you give broad passive immunity (outside of infancy), or does it have to be specific?